Benzoyl chloride, 3,4-dichloro- → 3,4-Dichloro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide

HRID 235909Notes

Reaction equation

HRID 235909 reaction equation
Cl.[O:2]1[CH:6]=[CH:5][C:4]([C:7]([CH2:9][NH2:10])=[O:8])=[CH:3]1.C(=O)(O)[O-].[Na+].[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[Cl:26])[C:20](Cl)=[O:21]>>[Cl:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=1[Cl:26])[C:20]([NH:10][CH2:9][C:7]([C:4]1[CH:5]=[CH:6][O:2][CH:3]=1)=[O:8])=[O:21]

Participants

4

Reactant 3

HCID 76403Benzoyl chloride, 3,4-dichloro-HCID 516892Sodium BicarbonateHCID 137731212-Amino-1-(furan-3-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 137731303,4-Dichloro-N-[2-(furan-3-yl)-2-oxoethyl]benzamideYield 82.4%

Procedure

5.0 g of (3-furylcarbonyl)methylamine hydrochloride, 6.5 g of sodium bicarbonate and 6.8 g of 3,4-dichlorobenzoyl chloride are treated in the same manner as described in Preparation 1-(1). 7.6 g of N-(3,4-dichlorobenzoyl)-(3-furylcarbonyl)methylamine are thereby obtained. Yield: 82.0%

Workup

  1. customas described in Preparation 1-(1)

Sources & evidence

ORD record
ord-ded926b3b2c84263897d366be4ffbb66
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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