Methyl iodide → HCID 67260331, compound

HRID 2359091Notes

Reaction equation

HRID 2359091 reaction equation
[Br:1][C:2]1[C:3]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)=[N:4][NH:5][C:6]=1[CH3:7].[H-].[Na+].I[CH3:17].[Cl-].[NH4+]>CN(C)C=O>[Br:1][C:2]1[C:3]([C:8]2[S:9][C:10]([Cl:13])=[CH:11][CH:12]=2)=[N:4][N:5]([CH3:17])[C:6]=1[CH3:7]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 67260636HCID 67260636, compound

Product 1

HCID 67260331HCID 67260331, compoundYield 54.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

4-Bromo-3-(5-chloro-2-thienyl)-5-methyl-1H-pyrazole (35.3 mmol) was dissolved in 30 mL dry N,N-dimethylformamide and cooled to 0° C. under nitrogen atmosphere. Sodium hydride (37.1 mmol, 60% dispersion in mineral oil) was added in portions at 0° C. After stirring for 30 min, iodomethane (42.4 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature and was stirred overnight. The solution was poured into saturated aqueous ammonium chloride solution and extracted with diethyl ether, dried over MgSO4, filtered and evaporated. The crude product was purified by chromatography on silica gel (100% dichloromethane) to afford 5.6 g 4-bromo-3-(5-chloro-2-thienyl)-1,5-dimethyl-1H-pyrazole (54% yield)

Workup

  1. temperatureto warm to room temperature
  2. stirringwas stirred overnight
  3. extractionextracted with diethyl ether
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated
  7. customThe crude product was purified by chromatography on silica gel (100% dichloromethane)

Sources & evidence

ORD record
ord-7f6d8929cb1b4c249ea4923371024b3d
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Reaction notes

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