Lithium diisopropylamide → HCID 58432069, compound

HRID 2359211Notes

Reaction equation

HRID 2359211 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)=[CH:4][C:3]=1[O:15][CH3:16].C([N-]C(C)C)(C)C.[Li+].[N:25]1[N:26]([C:30]2[CH:35]=[CH:34][C:33]([CH:36]([O:43][CH3:44])[C:37](N(OC)C)=[O:38])=[CH:32][CH:31]=2)[N:27]=[CH:28][CH:29]=1>C1COCC1>[N:25]1[N:26]([C:30]2[CH:31]=[CH:32][C:33]([CH:36]([O:43][CH3:44])[C:37]([C:12]3[O:11][C:10]([C:5]4[CH:6]=[C:7]([O:8][CH3:9])[C:2]([Br:1])=[C:3]([O:15][CH3:16])[CH:4]=4)=[CH:14][CH:13]=3)=[O:38])=[CH:34][CH:35]=2)[N:27]=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 2724682Lithium diisopropylamideHCID 584319882-(4-Bromo-3,5-dimethoxyphenyl)furanHCID 58432036HCID 58432036, compound

Product 1

HCID 58432069HCID 58432069, compoundYield 19.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
-78 °C

Procedure

To a solution of 2-(4-bromo-3,5-dimethoxyphenyl)furan (0.20 g, 0.71 mmol) in anhydr THF (10 mL) under argon in an oven-dried flask cooled to −78° C. was added lithium diisopropylamide (2.0 M in THF/heptane/ethylbenzene; 0.43 mL, 0.85 mmol) dropwise. After stirring for 1 hr at −78° C., a solution of 2-(4-(2H-1,2,3-triazol-2-yl)phenyl)-N,2-dimethoxy-N-methylacetamide (0.195 g, 0.71 mmol) in THF (2 mL) was added dropwise. After stirring for 25 min, the mixture was allowed to warm to room temp while stirring for 2 hrs. The reaction was quenched with the addition of saturated aqueous NH4Cl and EtOAc was added. The layers were separated and the organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by chromatography (30% EtOAc-hexanes) provided 2-(4-(2H-1,2,3-triazol-2-yl)phenyl)-1-(5-(4-bromo-3,5-dimethoxyphenyl)furan-2-yl)-2-methoxyethanone as a yellow solid (0.07 g, 10% yield). MS: m/z 497.9 [M+H]+.

Workup

  1. stirringAfter stirring for 25 min
  2. temperatureto warm to room temp
  3. stirringwhile stirring for 2 hrs
  4. customThe reaction was quenched with the addition of saturated aqueous NH4Cl and EtOAc
  5. additionwas added
  6. customThe layers were separated
  7. washthe organic layer was washed with brine
  8. dry with materialdried over Na2SO4
  9. concentrationconcentrated in vacuo
  10. customPurification by chromatography (30% EtOAc-hexanes)

Sources & evidence

ORD record
ord-73ed85cf22a54b599f7e054b4694d068
Source dataset
uspto-grants-2014_04
Patent number
US08685975B2

Reaction notes

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