反应详情

1-(5-Chloro-2-methoxyphenyl)ethanol (Preparation 4, 6.97 g, 37.3 mmol), was dissolved in trifluoroacetic acid (20 mL). Triethylsilane (29.8 mL, 187 mmol) was added and the reaction mixture stirred at room temperature overnight. The reaction mixture was concentrated in vacuo. The resulting residue was dissolved in ethyl acetate and washed with water. The organic phase was separated and concentrated in vacuo to afford the title compound (9 g, 141%, contains residual triethylsilane). This material was taken on crude in subsequent steps.

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionThe resulting residue was dissolved in ethyl acetate
3. washwashed with water
4. customThe organic phase was separated
5. concentrationconcentrated in vacuo