HCID 58046308, compound → HCID 58046311, compound

HRID 2359305Notes

Reaction equation

HRID 2359305 reaction equation
C([O:5][C:6](=[O:27])[C:7]1[CH:12]=[C:11]([Cl:13])[C:10]([O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([C:22]([F:25])([F:24])[F:23])[CH:16]=2)=[CH:9][C:8]=1[F:26])(C)(C)C>C(O)(C(F)(F)F)=O>[Cl:13][C:11]1[C:10]([O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([C:22]([F:25])([F:23])[F:24])[CH:16]=2)=[CH:9][C:8]([F:26])=[C:7]([CH:12]=1)[C:6]([OH:27])=[O:5]

Participants

3

Reactant 1

HCID 58046308HCID 58046308, compound

Product 1

HCID 58046311HCID 58046311, compoundYield 102.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

t-butyl-5-chloro-4-(4-chloro-3-(trifluoromethyl)phenoxy)-2-fluorobenzoate (Preparation 50, 245 mg, 0.58 mmol) was dissolved in TFA (4 mL) and the reaction stirred at room temperature for 2 h. The TFA was removed under reduced pressure to give the title compound (219 mg, quant.) as an off-white solid.

Workup

  1. customThe TFA was removed under reduced pressure

Sources & evidence

ORD record
ord-0fb54a8062004d71904c65dd769532a0
Source dataset
uspto-grants-2014_04
Patent number
US08685977B2

Reaction notes

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