反应详情

To a solution of 4-((3,4-dichlorophenyl)(hydroxy)methyl)-3-methoxybenzonitrile (165 mg, 0.535 mmol) in DMSO (3 mL) was added K2CO3 (222 mg, 1.60 mmol) followed by 30% H2O2 (1210 mg, 10.7 mmol) and the reaction was stirred at room temperature. After 45 minutes the product was purified without workup by direct injection onto a reverse phase column (Biotage C18-silica 12 g) eluting with 100:0:0.1 H2O:MeCN:HCO2H, to 0:100:0.1. The title compound was collected as a white solid (142 mg, 81%).

1. customAfter 45 minutes the product was purified without workup by direct injection onto a reverse phase column (Biotage C18-silica 12 g)
2. washeluting with 100:0:0.1 H2O
3. customThe title compound was collected as a white solid (142 mg, 81%)