Trifluoroacetic acid → HCID 58046335, compound

HRID 2359331Notes

Reaction equation

HRID 2359331 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:10]([S:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=2)=[CH:11][C:12]([F:22])=[C:13]([CH:21]=1)[C:14]([O:16]C(C)(C)C)=[O:15]>C(Cl)Cl>[Cl:8][C:9]1[C:10]([S:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=2)=[CH:11][C:12]([F:22])=[C:13]([CH:21]=1)[C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58046345HCID 58046345, compound

Product 1

HCID 58046335HCID 58046335, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (1.04 mL, 14 mmol) was added to a mixture of tert-butyl 5-chloro-4-(3,4-dichlorophenylthio)-2-fluorobenzoate (571 mg, 1.40 mmol) in DCM (10 mL) and the reaction stirred at room temperature for 18 hours. The reaction was concentrated to dryness to give the title compound as a white solid (492 mg, 100%). No further purification.

Workup

  1. concentrationThe reaction was concentrated to dryness

Sources & evidence

ORD record
ord-794f6e08535b45a4bba309b993f21723
Source dataset
uspto-grants-2014_04
Patent number
US08685977B2

Reaction notes

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