(-)-3-Hydroxytetrahydrofuran → HCID 58495746, compound

HRID 2359348Notes

Reaction equation

HRID 2359348 reaction equation
CC1C=CC(S([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:20][CH2:19][N:18](C(OCC3C=CC=CC=3)=O)[CH2:17][CH2:16]2)(=O)=O)=CC=1.[O:31]1[CH2:35][CH2:34][C@@H:33](O)[CH2:32]1>>[O:31]1[CH2:35][CH2:34][C@@H:33]([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[CH2:32]1

Participants

3

Reactant 2

HCID 641512(-)-3-HydroxytetrahydrofuranHCID 58495736HCID 58495736, compound

Product 1

HCID 58495746HCID 58495746, compoundYield 79%

Procedure

Using benzyl 4-(2-{[(4-methylphenyl)sulfony]oxy}ethoxy)piperidine-1-carboxylate (4.00 g, 9.23 mmol) produced in Reference Example 1 (1c) and (3R)-tetrahydrofuran-3-ol (1.05 g, 12.0 mmol), the desired title compound (1.56 g, yield 79%) was obtained by the same method as in Reference Examples 1 (1d) and 1 (1e).

Sources & evidence

ORD record
ord-5d5da2b532ba49c9998b8c5e3bc36ed6
Source dataset
uspto-grants-2014_04
Patent number
US08685981B2

Reaction notes

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