Triphosgene → HCID 58154781, compound

HRID 2359397Notes

Reaction equation

HRID 2359397 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[C:13]([NH2:20])[CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH:7]=[CH:8][CH:9]=1.Cl[C:24](Cl)([O:26]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[N:20]([C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:12]=1[N:11]=[C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:1])([F:21])[F:22])[CH:5]=1)[CH:19]=[CH:18]2)=[C:24]=[O:26]

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 58154581HCID 58154581, compound

Product 1

HCID 58154781HCID 58154781, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

2-(3-(trifluoromethoxy)phenyl)quinolin-8-amine (252 mg, 0.830 mmol) in toluene (10 mL) was added a mixture of triphosgene (82 mg, 0.275 mmol) in toluene (5 mL). The mixture was stirred for 2 days to obtain 8-isocyanato-2-(3-(trifluoromethoxy)phenyl)quinoline, which was used without isolation.

Sources & evidence

ORD record
ord-61e38c84c4524d34ba029dfd53142821
Source dataset
uspto-grants-2014_04
Patent number
US08685970B2

Reaction notes

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