反应详情

2-(5-methylpyridin-3-yl)quinoline-8-carboxylic acid (0.135 g, 0.51 mmol) was combined with DIPEA (0.140 mL, 0.811 mmol) and HATU (0.200 g, 0.51 mmol) in DMF (5 mL). The mixture was stirred at room temperature for ten minutes, at which time 6-(morpholinomethyl)pyridin-2-amine (0.090 g, 0.466 mmol) was added. The mixture was stirred 18 hours, and then water (10 mL) was added. The resulting precipitate was collected by filtration, and the solids were triturated in methanol to obtain 2-(5-methylpyridin-3-yl)-N-(6-(morpholinomethyl)pyridin-2-yl)quinoline-8-carboxamide as a tan solid (0.045 g, 22% yield. MS (ESI) calcd for C26H25N5O2 (m/z): 439.20. found: 440 [M+1].

1. additionwas added
2. filtrationThe resulting precipitate was collected by filtration
3. customthe solids were triturated in methanol