Trifluoroacetic acid → HCID 67190686, compound

HRID 2359650Notes

Reaction equation

HRID 2359650 reaction equation
C(OC(=O)[NH:7][C:8]1[C:9]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([C:27]#[N:28])[CH:22]=2)=[N:10][C:11]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[N:12][CH:13]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C:8]1[C:9]([O:20][C:21]2[CH:22]=[C:23]([CH:24]=[CH:25][CH:26]=2)[C:27]#[N:28])=[N:10][C:11]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[N:12][CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67192130HCID 67192130, compound

Product 1

HCID 67190686HCID 67190686, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Compound 14g (0.78 g; 2.0 mmol) in CH2Cl2 (20 mL) was added TFA (4 mL). The mixture was stirred at room temperature for 4 h. The solvent was evaporated under reduced pressure to afford Compound 14h. The crude product was used in the next reaction without further purification. MS: m/z 290.3 (M+H)+.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customto afford Compound 14h

Sources & evidence

ORD record
ord-d4cb3f931ee745588652887e93c4a1e7
Source dataset
uspto-grants-2014_04
Patent number
US08685990B2

Reaction notes

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