反应详情

To a solution of 3-methyl-isoxazol-5-ylamine in THF was added LiHMDS at −78° C., then the solution was stirred for 15 minutes, and 4′-(cyclopropylmethyl)-2-(methylsulfinyl)-4,5′-bipyrimidin-2′-amine (5-2) in THF was added to the reaction mixture. The reaction was warmed to rt and stirred for 1 hour. The reaction mixture was quenched with saturated ammonium chloride, extracted with ethyl acetate, dried over anhydrous sodium sulfate, and evaporated to give a crude product which was further purified by reverse-phase HPLC to give the desired product.

1. stirringstirred for 1 hour
2. customThe reaction mixture was quenched with saturated ammonium chloride
3. extractionextracted with ethyl acetate
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated
6. customto give a crude product which
7. customwas further purified by reverse-phase HPLC