反应详情

A solution of 94 (24 g, 0.108 mol), toluene, benzaldehyde (40 ml) and benzoic acid (0.5 g) was heated at reflux with a Dean-Stark trap. After 1 hour, the theoretical amount of H2O was collected, the reaction cooled to room temperature and saturated Na2CO3 added. The aqueous layer was separated and washed with CHCl3 (3×). The combined extracts were dried, filtered and concentrated to dryness to yield 34 g (100%) of 95.

1. temperatureat reflux with a Dean-Stark trap
2. customthe theoretical amount of H2O was collected
3. additionsaturated Na2CO3 added
4. customThe aqueous layer was separated
5. washwashed with CHCl3 (3×)
6. customThe combined extracts were dried
7. filtrationfiltered
8. concentrationconcentrated to dryness