Potassium Hydroxide → HCID 68547606, compound

HRID 2359837Notes

Reaction equation

HRID 2359837 reaction equation
[NH2:1][C:2]1[C:11]([C:12]([C:14]2[C:19]([O:20]C)=[CH:18][CH:17]=[CH:16][C:15]=2[O:22][CH3:23])=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.O.NN.[OH-].[K+]>C(O)COCCO>[NH2:1][C:2]1[C:11]([CH2:12][C:14]2[C:15]([O:22][CH3:23])=[CH:16][CH:17]=[CH:18][C:19]=2[OH:20])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

5

Reactant 3

HCID 14797Potassium Hydroxide2×HCID 24654Hydrazine hydrate (1:1)2×HCID 68555276HCID 68555276, compound

Product 1

HCID 68547606HCID 68547606, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Conditions

Temperature
160 °C

Procedure

(2-Aminoquinolin-3-yl)(2,6-dimethoxyphenyl)methanone (0.19 g, 0.6 mmol) was dissolved in diethylene glycol (10 mL), mixed with hydrazine hydrate (0.19 mL, 6.1 mmol) and pulverized potassium hydroxide (0.27 g, 6.7 mmol) and heated for 2 hours at 160° C. The same amounts of hydrazine hydrate and potassium hydroxide were added two more times and the reaction mixture was stirred for two more hours each time at 160° C.

Sources & evidence

ORD record
ord-713f64777da145abbf02804515a47ce6
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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