Potassium Hydroxide → HCID 68550298, compound

HRID 2359843Notes

Reaction equation

HRID 2359843 reaction equation
[NH2:1][C:2]1[C:11]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])=O)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:22][CH3:23])[CH:8]=2)[N:3]=1.O.NN.[OH-].[K+]>C(O)COCCO>[CH3:23][O:22][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH2:1])[C:11]([CH2:12][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21])=[CH:10]2

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 68554149HCID 68554149, compound

Product 1

HCID 68550298HCID 68550298, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Conditions

Temperature
160 °C

Procedure

(2-Amino-6-methoxyquinolin-3-yl)(2-methoxyphenyl)methanone (1.1 g, 3.6 mmol) was dissolved in diethylene glycol (15 mL), mixed with hydrazine hydrate (0.56 mL, 18 mmol) and pulverized potassium hydroxide (1.1 g, 19.8 mmol) and heated to 160° C. for 1.5 hours.

Sources & evidence

ORD record
ord-a532f0c16de2430ea9ee216012672185
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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