D-Tartaric acid → HCID 86658826, compound

HRID 2360068Notes

Reaction equation

HRID 2360068 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([OH:39])(=[O:38])[C@H:31]([C@@H:33]([C:35]([OH:37])=[O:36])[OH:34])[OH:32]>CO>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:35]([C@H:33]([C@@H:31]([C:30]([O-:39])=[O:38])[OH:32])[OH:34])([O-:37])=[O:36]

Participants

4

Reactant 2

HCID 439655D-Tartaric acidHCID 5329102Sunitinib

Product 1

HCID 86658826HCID 86658826, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sunitinib (2.20, 5.52 mmol) was suspended in methanol (100 ml). 0.83 g of D-tartaric acid was added. Mixture was heated until all material was dissolved, then left to cool to room temperature to form crystalline sunitinib D-tartrate, 2.95 g. Melting point 183-187° C. (form II)

Workup

  1. temperatureMixture was heated until all material
  2. dissolutionwas dissolved
  3. waitleft

Sources & evidence

ORD record
ord-42a52ecb3f3e41d9a8bb3131903005c5
Source dataset
uspto-grants-2014_04
Patent number
US08686023B2

Reaction notes

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