L-Tartaric acid → HCID 86658827, compound

HRID 2360069Notes

Reaction equation

HRID 2360069 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([OH:39])(=[O:38])[C@@H:31]([C@H:33]([C:35]([OH:37])=[O:36])[OH:34])[OH:32]>CO>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:35]([C@@H:33]([C@H:31]([C:30]([O-:39])=[O:38])[OH:32])[OH:34])([O-:37])=[O:36]

Participants

4

Reactant 2

HCID 444305L-Tartaric acidHCID 5329102Sunitinib

Product 1

HCID 86658827HCID 86658827, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sunitinib (2.15, 5.40 mmol) was suspended in methanol (100 ml). 0.81 g of L-tartaric acid was added. Mixture was heated until all material was dissolved, then left to cool to room temperature to form crystalline sunitinib L-tartrate, 2.1 g. Melting point: 189-193° C. (form II)

Workup

  1. temperatureMixture was heated until all material
  2. dissolutionwas dissolved
  3. waitleft

Sources & evidence

ORD record
ord-1b73067c00b44db990fcd6a7fd8c9327
Source dataset
uspto-grants-2014_04
Patent number
US08686023B2

Reaction notes

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