Phenylboronic Acid → HCID 46314623, compound

HRID 2360405Notes

Reaction equation

HRID 2360405 reaction equation
[F:1][C:2]1[CH:8]=[C:7](Br)[CH:6]=[C:5]([F:10])[C:3]=1[NH2:4].[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[F:1][C:2]1[CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[C:5]([F:10])[C:3]=1[NH2:4]

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 6101914-Bromo-2,6-difluoroaniline

Product 1

HCID 46314623HCID 46314623, compoundYield 81.4%

Procedure

The title compound (0.401 g) was prepared from 2,6-difluoro-4-bromo aniline (0.5 g, 2.4 mmol) and phenylboronic acid (0.38 g, 3.12 mmol) as a white solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 7.60 (d, J 7.4, 2H), 7.38 (t, J 7.5, 2H), 7.30-7.25 (m, 3H), 5.33 (s, 2H).

Sources & evidence

ORD record
ord-1f068def37344b3d8c555d7ce34d5ac4
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

Loading…