Hydrochloric Acid → HCID 66986088, compound

HRID 2360486Notes

Reaction equation

HRID 2360486 reaction equation
[CH3:1][O:2][C@H:3]1[CH2:7][N:6](C(OC(C)(C)C)=O)[C@@H:5]([C:15]([O-:17])=[O:16])[CH2:4]1.[ClH:18]>O1CCCC1.C(#N)C>[ClH:18].[CH3:1][O:2][C@H:3]1[CH2:7][NH:6][C@@H:5]([C:15]([OH:17])=[O:16])[CH2:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 28180053HCID 28180053, compound

Product 1

HCID 66986088HCID 66986088, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8028TetrahydrofuranSolvent

Procedure

8.72 g 1-tert-butyl (2R,4R)-4-methoxy-pyrrolidine-1,2-dicarboxylate are dissolved in 60 ml of tetrahydrofuran, combined dropwise with 60 ml of a 6 M aqueous hydrochloric acid solution and stirred for 4 hours at ambient temperature. Then the solvents are eliminated in vacuo and the residue is taken up twice in 100 ml acetonitrile and the latter is in each case eliminated again in vacuo.

Sources & evidence

ORD record
ord-f0e477ad0b924d94be77d3784b067cf1
Source dataset
uspto-grants-2014_04
Patent number
US08686022B2

Reaction notes

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