Hydrochloric Acid → HCID 66986035, compound

HRID 2360492Notes

Reaction equation

HRID 2360492 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:40][S:41]([CH3:44])(=[O:43])=[O:42])[C:8]([O:38][CH3:39])=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:37])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:23][N:24]2[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]2)=[O:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].CO.[ClH:47]>C(O)(C)C>[ClH:47].[ClH:47].[C:1]([C:5]1[CH:6]=[C:7]([NH:40][S:41]([CH3:44])(=[O:43])=[O:42])[C:8]([O:38][CH3:39])=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:37])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:23][N:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)=[O:13])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11563567HCID 11563567, compound

Product 1

HCID 66986035HCID 66986035, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2.29 g tert-butyl 4-[2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperazine-1-carboxylate are dissolved in 25 ml of a 5 M solution of HCl in isopropanol and stirred for 12 hours at ambient temperature. Then the solvents are eliminated in vacuo and the residue is twice taken up with 20 ml of methanol and this is then eliminated again in vacuo.

Sources & evidence

ORD record
ord-0c8150ad63c340a1be3e2fb23b070b23
Source dataset
uspto-grants-2014_04
Patent number
US08686022B2

Reaction notes

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