反应详情

A solution of 3-trifluoromethyl 4-fluoro-benzonitrile (9.45 g, 50 mmol) and diethanolamine (15.8 g, 0.15 mol) in N,N-dimethylacetamide (200 ml) was stirred for 7 days at 50° C. The solvent was evaporated, the residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml), the organic layer dried (MgSO4) and evaporated to dryness. The residue was chromatographed using CH2Cl2-EtOH as eluent.

1. customThe solvent was evaporated
2. customthe residue partitioned between CH2Cl2 (400 ml) and H2O (400 ml)
3. dry with materialthe organic layer dried (MgSO4)
4. customevaporated to dryness
5. customThe residue was chromatographed