反应详情

To a yellow, homogeneous solution of ethyl 4-(2-fluorophenyl)-7-(morpholine-4-carbonyl)-9H-pyrido[3,4-b]indole-1-carboxylate (0.0592 g, 0.132 mmol) in THF (2.84 mL) and MeOH (0.945 mL) was added LiOH (0.022 g, 0.529 mmol) in water (0.5 mL). After 2 hr, the reaction mixture was concentrated in vacuo, and the residue was diluted with water and acidified with 1N aq. HCl to pH ˜4 by litmus paper. The mixture was extracted with EtOAc (3×), and the organic layers were combined, dried over Na2SO4, and concentrated in vacuo to give the desired product (0.0382 g, 0.091 mmol, 68.8% yield) as a yellow solid.

1. concentrationthe reaction mixture was concentrated in vacuo
2. additionthe residue was diluted with water
3. extractionThe mixture was extracted with EtOAc (3×)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo