Oxalyl chloride → HCID 66605334, compound

A solution of crude 2-(bromomethyl)-5-fluorobenzoic acid (3.05 g, 13.1 mmol) in CH2Cl2 (50 mL) was treated with oxalyl chloride (1.66 g, 13.1 mmol) and 6 drops of DMF. The mixture was stirred at room temperature for 1 h, and then was concentrated. The residue was dissolved in CH2Cl2 (50 mL) and treated with 3-bromo-2-methylaniline (1.705 g, 9.16 mmol). The mixture was stirred at room temperature for 1 h, and then TEA (2.19 mL, 15.7 mmol) was added in portions. The mixture was stirred at room temperature for 2 h, then was diluted with CH2Cl2 (100 mL), washed with NaHCO3 (aq) and water, dried and concentrated. The residue was triturated with CH2Cl2 to provide the desired product as a white solid (0.9 g). The mother liquor was concentrated and the residue was again triturated with CH2Cl2 to provide additional desired product as a white solid (0.46 g). The mother liquor was concentrated and the residue was purified by column chromatography on silica gel, eluting with EtOAc-hexane (gradient from 0:100 to 30:70) to provide additional desired product as a pink solid (1.18 g) for a total of 2.54 g (48% yield). LCMS (M+H)+ m/z 400, 402, 404.

1. concentrationwas concentrated
2. dissolutionThe residue was dissolved in CH2Cl2 (50 mL)
3. stirringThe mixture was stirred at room temperature for 1 h
4. stirringThe mixture was stirred at room temperature for 2 h
5. washwashed with NaHCO3 (aq) and water
6. customdried
7. concentrationconcentrated
8. customThe residue was triturated with CH2Cl2

ORD record

ord-2355ecc1cb0c41b99d56c988029a40f1

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08685969B2