Diethylamine → Diethylamino propionic acid ethyl ester

HRID 2361532Notes

Reaction equation

HRID 2361532 reaction equation
Br[CH:2]([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:9]([NH:11][CH2:12][CH3:13])[CH3:10]>>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([N:11]([CH2:12][CH3:13])[CH2:9][CH3:10])[CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 79040Ethyl 2-bromopropionate

Product 1

HCID 13010788Diethylamino propionic acid ethyl esterYield 80%

Procedure

To ethyl 2-bromopropionate (0.15 moles), diethylamine (0.4 moles) was added, followed by stirring for 10 hours at room temperature. White solid was removed by filtration, and then the filtrate was distilled to obtain 2-diethylaminopropionic acid ethyl ester (0.120 moles).

Workup

  1. customWhite solid was removed by filtration
  2. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-6d391d24a9ee4ac98d7bf64f866fe158
Source dataset
uspto-grants-2014_04
Patent number
US08691352B2

Reaction notes

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