反应详情

1-[(3-azidoazetidin-1-yl)carbonyl]-4-cyclobutyl-1,4-diazepane (140 mg, 0.50 mmol), was dissolved in THF (5 ml) and water (0.28 ml, 5 mmol) was added. PPh3 was then added as a solid and the reaction was stirred for 16 hours giving a clear solution. The reaction was concentrated in vacuo and purified by FCC (DCM/MeOH/MH3 gradient, 95:5:1 to 70:30:1) to provide the title compound as pale yellow solid (51 mg, 40%).

1. customgiving a clear solution
2. concentrationThe reaction was concentrated in vacuo
3. custompurified by FCC (DCM/MeOH/MH3 gradient, 95:5:1 to 70:30:1)