Ethane, 2-bromo-1,1-diethoxy- → HCID 37979251, compound

HRID 2361971Notes

Reaction equation

HRID 2361971 reaction equation
Br[CH2:2][CH:3]([O:7][CH2:8][CH3:9])[O:4][CH2:5][CH3:6].[C:10]1([C@H:16]([NH2:18])[CH3:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:5]([O:4][CH:3]([O:7][CH2:8][CH3:9])[CH2:2][NH:18][C@@H:16]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:17])[CH3:6]

Participants

3

Reactant 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 6431891-Phenethylamine, (+)-

Product 1

HCID 37979251HCID 37979251, compoundYield 71.8%

Procedure

According to the procedure described in the synthesis method of Compound IX-1, 2-bromo-1,1-diethoxyethane (41.3 ml, 270 mmol) was reacted with (R)-(+)-1-phenylethylamine (66.6 g, 550 mmol) and the obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=5:1 and 1:1) to obtain the title compound (46.0 g, 70%).

Workup

  1. customthe obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=5:1 and 1:1)

Sources & evidence

ORD record
ord-333e5a2fb31f4df9a157d821a8d17959
Source dataset
uspto-grants-2014_04
Patent number
US08691819B2

Reaction notes

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