Dimethylformamide dimethyl acetal → HCID 66823376, compound

HRID 2362152Notes

Reaction equation

HRID 2362152 reaction equation
[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:28])[CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:16][CH:15]=2)[CH2:11][C:10]([OH:13])([CH3:12])[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:30][N:31]([CH:33](OC)OC)[CH3:32]>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1([C:14]2[CH:15]=[CH:16][C:17]([C:20](=[O:28])[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:30][N:31]([CH3:33])[CH3:32])=[CH:18][CH:19]=2)[CH2:9][C:10]([OH:13])([CH3:12])[CH2:11]1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 66709074HCID 66709074, compound

Product 1

HCID 66823376HCID 66823376, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of compound 2-3 (3.96 g, 10 mmol) in toluene (20 mL) was added DMFDMA (9.2 g, 35 mmol) and the mixture was heated at reflux for 4 hours. The mixture was cooled and the formed white solid was collected. After washed by PE, the solid was dried in vacuum to get the product 2.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 4 hours
  3. temperatureThe mixture was cooled
  4. customthe formed white solid was collected
  5. washAfter washed by PE
  6. customthe solid was dried in vacuum

Sources & evidence

ORD record
ord-707847a1e62f4ff79a5973454c5b71b9
Source dataset
uspto-grants-2014_04
Patent number
US08691825B2

Reaction notes

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