Trifluoroacetic acid → HCID 66719151, compound

HRID 2362186Notes

Reaction equation

HRID 2362186 reaction equation
C(OC(=O)[NH:7][C:8]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[C:23]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:22][N:21]4[N:30]=[C:31]([C:39]5[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=5)[C:32]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[C:20]4[N:19]=3)=[CH:14][CH:13]=2)[CH2:11][CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:39]1([C:31]2[C:32]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[C:20]3[N:19]=[C:18]([C:15]4[CH:16]=[CH:17][C:12]([C:8]5([NH2:7])[CH2:9][CH2:10][CH2:11]5)=[CH:13][CH:14]=4)[C:23]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:22][N:21]3[N:30]=2)[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66823510HCID 66823510, compound

Product 1

HCID 66719151HCID 66719151, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of 9-5 (60 mg, 0.1 mmol) in 1 mL of DCM was added TFA (1 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 9-6.

Workup

  1. concentrationThe mixture was concentrated by evaporation
  2. customthe residue was purified by prep.HPLC

Sources & evidence

ORD record
ord-05d0f7714d27445389071569ca4fe9f8
Source dataset
uspto-grants-2014_04
Patent number
US08691825B2

Reaction notes

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