HCID 67960315, compound → HCID 67958706, compound

HRID 2362327Notes

Reaction equation

COC1C=CC(C[N:8]2[C:16]3[C:15](=[O:17])[N:14]([CH2:18][C:19]4[N:28]=[C:27]([CH3:29])[C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[N:20]=4)[C:13]4=[N:30][CH2:31][CH2:32][N:12]4[C:11]=3[N:10]=[CH:9]2)=CC=1>C(O)(C(F)(F)F)=O>[CH3:29][C:27]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:20]=[C:19]([CH2:18][N:14]2[C:15](=[O:17])[C:16]3[NH:8][CH:9]=[N:10][C:11]=3[N:12]3[CH2:32][CH2:31][N:30]=[C:13]23)[N:28]=1

Participants

Conditions

Temperature: 70 °C

Procedure

To 3-(4-methoxybenzyl)-5-((4-methylquinazolin-2-yl)methyl)-7,8-dihydro-3H-imidazo[2,1-b]pinin-4(5H)-one 13 (858 mg, 1.89 mmol) was added TFA (20 ml), and stirred at 70° C. over night. The mixture was concentrated and purified by flash chromatography (MeOH/DCM, MeOH contains 10% ammonia) to afford the product 5-((4-methylquinazolin-2-yl)methyl)-7,8-dihydro-3H-imidazo[2,1-b]purin-4(5H)-one 14.

Workup

concentrationThe mixture was concentrated
custompurified by flash chromatography (MeOH/DCM, MeOH contains 10% ammonia)

Sources & evidence

ORD record: ord-8040b160719443a3bd5265353c3833b5
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08691832B2

Reaction notes

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