Water → HCID 86673428, compound

HRID 2362391Notes

Reaction equation

HRID 2362391 reaction equation
FC1C=CC(F)=C[C:3]=1[CH2:4][P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8].BrCC1[N:25]=[C:24]([Cl:26])[CH:23]=[CH:22][N:21]=1.O.C(O)(C(F)(F)F)=O>CC#N>[CH2:10]([O:9][P:5]([CH2:4][C:3]1[N:25]=[C:24]([Cl:26])[CH:23]=[CH:22][N:21]=1)(=[O:12])[O:6][CH2:7][CH3:8])[CH3:11]

Participants

6

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 59525761HCID 59525761, compoundHCID 86673423HCID 86673423, compound

Product 1

HCID 86673428HCID 86673428, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared according to the same procedure as diethyl 2,5-difluorobenzylphosphonate, starting with 2-(bromomethyl)-4-chloropyrimidine. Analytical HPLC method: Phenomenex LUNA C18, 50×2 3μ, A=90% H2O/10% CH3CN, B=90% CH3CN/10% H2O, Modifier 0.1% TFA, 0.00 min=0% B, 4.0 min=100% B, 5.0 min=100% B, Flow rate=0.8 mL/min. Mass spec.: 265.1 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9c1bcbd9f2d94edcab471e4c52f6c9be
Source dataset
uspto-grants-2014_04
Patent number
US08691821B2

Reaction notes

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