Water → HCID 136379490, compound

HRID 2362661Notes

Reaction equation

HRID 2362661 reaction equation
[Cl:1][C:2]1[C:3]([C:30]2[S:34][C:33]([C:35]3([O:39][CH2:40][O:41][CH3:42])[CH2:38][CH2:37][CH2:36]3)=[N:32][CH:31]=2)=[C:4]2[CH:10]=[C:9]([C:11]([O:13]/[N:14]=[C:15](/[CH:17]3[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH2:18]3)\[NH2:16])=O)[NH:8][C:5]2=[N:6][CH:7]=1.O>CN1CCCC1=O>[Cl:1][C:2]1[C:3]([C:30]2[S:34][C:33]([C:35]3([O:39][CH2:40][O:41][CH3:42])[CH2:36][CH2:37][CH2:38]3)=[N:32][CH:31]=2)=[C:4]2[CH:10]=[C:9]([C:11]3[O:13][N:14]=[C:15]([CH:17]4[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:28])([CH3:29])[CH3:27])=[O:24])[CH2:19][CH2:18]4)[N:16]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 962WaterHCID 141316782HCID 141316782, compound

Product 1

HCID 136379490HCID 136379490, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of Example 46D (0.66 g, 0.107 mmol) in 1-methyl-2-pyrrolidinone (1.2 mL) was heated at 110° C. for 5 hours. The reaction was cooled to ambient temperature and poured into water (5 mL). The resulting suspension was filtered, and the solid collected was washed with water and dried under vacuum to provide the title compound. MS ESI(+) m/z 601.2 [M+H]+.

Workup

  1. filtrationThe resulting suspension was filtered
  2. customthe solid collected
  3. washwas washed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-6908b25e31474544a04704655456fedc
Source dataset
uspto-grants-2014_04
Patent number
US08691810B2

Reaction notes

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