Potassium Carbonate → HCID 67003487, compound

HRID 2362747Notes

Reaction equation

HRID 2362747 reaction equation
Cl[CH2:2]/[CH:3]=[CH:4]/[B:5]1[O:9][C:8]([CH3:11])([CH3:10])[C:7]([CH3:13])([CH3:12])[O:6]1.C(=O)([O-])[O-].[K+].[K+].[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>C(#N)C>[CH3:12][C:7]1([CH3:13])[C:8]([CH3:11])([CH3:10])[O:9][B:5](/[CH:4]=[CH:3]/[CH2:2][N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[O:6]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 118305003-Chloropropenyl-1-boronic acid pinacol ester

Product 1

HCID 67003487HCID 67003487, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of (E)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1 g, 4.94 mmol) in acetonitrile (10 mL) was treated with potassium carbonate (1.366 g, 9.88 mmol) and pyrrolidine (0.531 mL, 6.42 mmol). The suspension was stirred at ambient temperature for 20 hours. The reaction mixture was filtered and the filtrate was concentrated on a rotary evaporator to provide the title compound. MS ESI(+) m/z 238.2 [M+H]+.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated on a rotary evaporator

Sources & evidence

ORD record
ord-7a63b866fa984f5c98de62a2382dc72e
Source dataset
uspto-grants-2014_04
Patent number
US08691810B2

Reaction notes

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