反应详情

1-Bromobutane (3.75 g, 27.33 mmol) and potassium carbonate (10.3 g, 74.52 mmol) were added to a solution of 4-benzyloxy-1H-pyridin-2-one (5.0 g, 24.84 mmol) in acetonitrile (200 ml) and the mixture was heated at reflux temperature for 16 hours. Subsequently, the reaction mixture was filtered through diatomaceous earth and concentrated in vacuo. The crude residue was then triturated with diethyl ether to yield pure D4 (6.26 g, 98%) as a white solid.

1. temperaturethe mixture was heated
2. temperatureat reflux temperature for 16 hours
3. filtrationSubsequently, the reaction mixture was filtered through diatomaceous earth
4. concentrationconcentrated in vacuo
5. customThe crude residue was then triturated with diethyl ether