反应详情

温度

180 °C

A mixture of 3-bromophenol (2.4 g, 13.9 mmol), bomocyclopropane (6.66 ml, 83 mmol) and potassium carbonate (9.6 g, 69.5 mmol) in DMF (16 ml) was heated at 180° C. in a microwave oven for 8 hours. The reaction mixture was diluted with a mixture of diethylether and water. The organic layer was separated, washed with water, brine, dried over Na2SO4, filtered and evaporated. An oil was obtained, 2.87 g, with a purity of 81%. This intermediate was used for the next reaction.

1. customThe organic layer was separated
2. washwashed with water, brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated
6. customAn oil was obtained
7. customThis intermediate was used for the next reaction