Hydrochloric Acid → HCID 66652211, compound

HRID 2362874Notes

Reaction equation

HRID 2362874 reaction equation
[C@@H:1]([O:5][C:6]([C:8]1[CH:9]=[C:10]([CH:36]=[CH:37][CH:38]=1)[CH2:11][N:12]1[C:16](=[O:17])[C:15]2([CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)[N:14]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:13]1)=[O:7])([CH2:3][CH3:4])[CH3:2].Cl>O1CCOCC1>[O:17]=[C:16]1[C:15]2([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[N:14]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:13][N:12]1[CH2:11][C:10]1[CH:9]=[C:8]([CH:38]=[CH:37][CH:36]=1)[C:6]([O:5][C@H:1]([CH2:3][CH3:4])[CH3:2])=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046642HCID 58046642, compound

Product 1

HCID 66652211HCID 66652211, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To (S)-tert-butyl 3-(3-(sec-butoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.072 g, 0.14 mmol) was added 4M solution of HCl in dioxane (1.5 mL). After stirring at room temperature for an hour, the reaction mixture was concentrated in vacuo to obtain (S)-sec-butyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-2f5046494b4846bdbe3204251fcf65fd
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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