Hydrochloric Acid → HCID 66652067, compound

HRID 2362885Notes

Reaction equation

HRID 2362885 reaction equation
[CH2:1]([N:3]([CH2:41][CH3:42])[C:4](=[O:40])[CH2:5][O:6][C:7]([C:9]1[CH:10]=[C:11]([CH:37]=[CH:38][CH:39]=1)[CH2:12][N:13]1[C:17](=[O:18])[C:16]2([CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[N:15]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:14]1)=[O:8])[CH3:2].Cl>O1CCOCC1>[O:18]=[C:17]1[C:16]2([CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:15]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:14][N:13]1[CH2:12][C:11]1[CH:10]=[C:9]([CH:39]=[CH:38][CH:37]=1)[C:7]([O:6][CH2:5][C:4]([N:3]([CH2:41][CH3:42])[CH2:1][CH3:2])=[O:40])=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046775HCID 58046775, compound

Product 1

HCID 66652067HCID 66652067, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(3-((2-(diethylamino)-2-oxoethoxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.22 g, 0.38 mmol) was added 4M solution of HCl in dioxane (3 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 2-(diethylamino)-2-oxoethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-6a47c1e7a5014a46ba0f649737722879
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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