Hydrochloric Acid → HCID 66652084, compound

HRID 2362899Notes

Reaction equation

HRID 2362899 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:44])[CH2:9][O:10][C:11]([C:13]2[CH:14]=[C:15]([CH:41]=[CH:42][CH:43]=2)[CH2:16][N:17]2[C:21](=[O:22])[C:20]3([CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]3)[N:19]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:18]2)=[O:12])[CH2:4][CH2:3]1.Cl>O1CCOCC1>[O:22]=[C:21]1[C:20]2([CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:19]([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH2:18][N:17]1[CH2:16][C:15]1[CH:14]=[C:13]([CH:43]=[CH:42][CH:41]=1)[C:11]([O:10][CH2:9][C:8]([N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1)=[O:44])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046633HCID 58046633, compound

Product 1

HCID 66652084HCID 66652084, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(3-((2-(4-methylpiperazin-1-yl)-2-oxoethoxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.16 g, 0.26 mmol) was added 4M solution of HCl in dioxane (3 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 2-(4-methylpiperazin-1-yl)-2-oxoethyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c0ecb1811f294880b5756257dc3706cd
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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