HCID 53791715, compound → HCID 54485518, compound

HRID 236296Notes

Reaction equation

HRID 236296 reaction equation
[NH2:1][C:2]1[N:7]([CH:8]2[CH2:11][CH2:10][CH2:9]2)[C:6](=[O:12])[NH:5][C:4](=[O:13])[C:3]=1[N:14]=O>CN(C=O)C.O=[Pt]=O>[CH:8]1([N:7]2[C:2]([NH2:1])=[C:3]([NH2:14])[C:4](=[O:13])[NH:5][C:6]2=[O:12])[CH2:9][CH2:10][CH2:11]1

Participants

4

Reactant 1

HCID 53791715HCID 53791715, compound

Product 1

HCID 54485518HCID 54485518, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 6228DimethylformamideSolvent

Procedure

6.9 g of 6-amino-1-cyclobutyl-5-nitroso-2,4-(1H,3H)-pyrimidinedione (IX) was catalytically hydrogenated in 250 ml of DMF and in the presence of 0.1 g PtO2 for 2 hours and at room temperature and at a pressure of 200 kPa. The catalyst and the crystals were filtered off and washed with ethanol. Yield 3.5 g (54%) (X).

Workup

  1. filtrationThe catalyst and the crystals were filtered off
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-b917733375074e5e94940f3c16631670
Source dataset
uspto-grants-1987_02
Patent number
US04644001

Reaction notes

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