1-Methylidene-2,3-dihydro-1H-inden-4-ol → 1-Methyl-2,3-dihydro-1H-inden-4-ol

HRID 2363104Notes

Reaction equation

HRID 2363104 reaction equation
[CH2:1]=[C:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH2:4][CH2:3]1.[H][H]>CO.CCOC(C)=O.[Pd]>[CH3:1][CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([OH:11])[C:5]=2[CH2:4][CH2:3]1

Participants

6

Reactant 2

HCID 450828201-Methylidene-2,3-dihydro-1H-inden-4-olHCID 178418361HCID 178418361, compound

Product 1

HCID 893101-Methyl-2,3-dihydro-1H-inden-4-olYield 93,579.297%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1-methylene-indan-4-ol (200 mg, 1.37 mmol) and 10% Pd/C (60 mg, 10% weight) in methanol (6 ml) was hydrogenated under 50 psi hydrogen atmosphere for 1 hour. The mixture was dissolved in EtOAc, filtered through a celite pad. The filtrate was concentrated under reduced pressure, and dried to give 1-methyl-indan-4-ol (190 g, 94%)

Workup

  1. filtrationfiltered through a celite pad
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-70ae8c466e8b4593ae071fdcf04c12c0
Source dataset
uspto-grants-2014_04
Patent number
US08691855B2

Reaction notes

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