Isopropanol → Isopropyl chloro(oxo)acetate

HRID 2363248Notes

Reaction equation

HRID 2363248 reaction equation
[CH:1]([OH:4])([CH3:3])[CH3:2].[C:5](Cl)(=[O:9])[C:6]([Cl:8])=[O:7]>>[CH:1]([O:4][C:5](=[O:9])[C:6]([Cl:8])=[O:7])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 3776IsopropanolHCID 65578Oxalyl chloride

Product 1

HCID 11355577Isopropyl chloro(oxo)acetate

Procedure

Isopropanol (158 μL, 2.1 mmol, 1.0 eq.) was added dropwise over 5 minutes to oxalyl chloride (350 μL, 4.14 mmol, 2.0 eq.) at 0° C., and the resulting mixture was stirred at room temperature for 2 hours. The excess oxalyl chloride was removed by rotary evaporation (40° C., 50 mmHg) and used without further purification.

Workup

  1. customThe excess oxalyl chloride was removed by rotary evaporation (40° C., 50 mmHg)
  2. customused without further purification

Sources & evidence

ORD record
ord-cdb7799916274794b599ecc7dc6dbae5
Source dataset
uspto-grants-2014_04
Patent number
US08691868B2

Reaction notes

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