4-Fluoroaniline → HCID 13370093, compound

HRID 236351Notes

Reaction equation

HRID 236351 reaction equation
[O:1]=[C:2]([C:11]1[NH:12][CH:13]=[CH:14][CH:15]=1)[CH:3]([C:6]([O:8]CC)=O)[C:4]#[N:5].[F:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>C1(C)C(C)=CC=CC=1>[O:1]=[C:2]([C:11]1[NH:12][CH:13]=[CH:14][CH:15]=1)[CH:3]([C:6](=[O:8])[NH:21][C:20]1[CH:22]=[CH:23][C:17]([F:16])=[CH:18][CH:19]=1)[C:4]#[N:5]

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 13370096HCID 13370096, compound

Product 1

HCID 13370093HCID 13370093, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 1.1 g of β-oxo-α-ethoxycarbonyl-β-(2-pyrrolyl)-propionitrile, 1.5 g of 4-fluoroaniline and 60 ml of xylene, is refluxed for 41/2 hours. After standing and cooling to room temperature overnight, the solution is filtered, evaporated and the residue is purified to yield β-oxo-α-(4-fluorophenyl carbamoyl)-β-(2-pyrrolyl)-propionitrile of example 5.

Workup

  1. temperatureis refluxed for 41/2 hours
  2. filtrationthe solution is filtered
  3. customevaporated
  4. customthe residue is purified

Sources & evidence

ORD record
ord-eb3ce7988f184c5385f97ef3937c6313
Source dataset
uspto-grants-1987_02
Patent number
US04644010

Reaction notes

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