Ammonium Hydroxide → HCID 178515044, compound

HRID 236400Notes

Reaction equation

HRID 236400 reaction equation
[NH:1]1[C:5]([NH:6][CH:7]=[N:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([O:17]C)=O)=[N:4][N:3]=[N:2]1.[OH-].[NH4+]>CO>[NH:1]1[C:5]([N:6]2[C:15](=[O:17])[C:10]3[C:9](=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:8]=[CH:7]2)=[N:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 178497644HCID 178497644, compound

Product 1

HCID 178515044HCID 178515044, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A slurry of 3 g of N1 -(1H-tetrazol-5-yl)-N2 -(2-carbomethoxyphenyl)formamidine in 10 ml of methanol was stirred at room temperature. A solution of 0.8 ml of 14.8M ammonium hydroxide in 5 ml of methanol was added to the mixture which was stirred for 1 hour. The white solid which formed was separated by filtration, washed with aqueous 2-propanol and vacuum oven dried to give the ammonium salt of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone.

Workup

  1. customThe white solid which formed
  2. customwas separated by filtration
  3. washwashed with aqueous 2-propanol and vacuum oven
  4. customdried

Sources & evidence

ORD record
ord-b966159e09284e878c67213a7d734f12
Source dataset
uspto-grants-1987_02
Patent number
US04644065

Reaction notes

Loading…