Hydrochloric Acid → HCID 66743846, compound

HRID 2364026Notes

Reaction equation

HRID 2364026 reaction equation
[Br:1][C:2]1[C:6]2[N:7](C)[C:8](C)(C)[NH:9][C:10](=[O:11])[C:5]=2[S:4][C:3]=1[C:15]1[CH:16]=[N:17][NH:18][CH:19]=1.[ClH:20]>CO>[ClH:20].[ClH:20].[Br:1][C:2]1[C:6]([NH:7][CH3:8])=[C:5]([C:10]([NH2:9])=[O:11])[S:4][C:3]=1[C:15]1[CH:16]=[N:17][NH:18][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66743399HCID 66743399, compound

Product 1

HCID 66743846HCID 66743846, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 7-bromo-1,2,2-trimethyl-6-(1H-pyrazol-4-yl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one (171 mg, 0.50 mmol), 1 M HCl (2.5 mL, 2.50 mmol) and MeOH (5 mL) was stirred at 50° C. for 1 h. The mixture was concentrated under reduced pressure to afford the title compound (182 mg, 97%) as a pale yellow solid. This material was used for the next reaction without further purification.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a65204737e1747f78dcd68e78f3012da
Source dataset
uspto-grants-2014_04
Patent number
US08691828B2

Reaction notes

Loading…