反应详情

温度

50 °C

A mixture of 1,2,2-trimethyl-6-(5-methyl-1H-pyrazol-4-yl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one (378 mg, 1.37 mmol), 1 M HCl (4.79 mL) and MeOH (12 mL) was stirred for 2 h at 50° C. The mixture was poured into excess saturated aqueous NaHCO3 and extracted with 3:1 EtOAc/THF, and the extract was dried over MgSO4, filtered and concentrated under reduced pressure. The residue was triturated with ethanol (6 mL) and collected by filtration to afford the title compound (183 mg, 57%) as a pale yellow solid:

1. extractionextracted with 3:1 EtOAc/THF
2. dry with materialthe extract was dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customThe residue was triturated with ethanol (6 mL)
6. filtrationcollected by filtration