Methyl iodide → HCID 69482769, compound

HRID 2364299Notes

Reaction equation

HRID 2364299 reaction equation
[NH2:1][C:2]1[C:3]([C:16]([O:18][CH3:19])=[O:17])=[N:4][CH:5]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:7]=1.F[C:21](F)(F)C(OC(=O)C(F)(F)F)=O.CI>CO>[F:15][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][C:6]2[CH:7]=[C:2]([NH:1][CH3:21])[C:3]([C:16]([O:18][CH3:19])=[O:17])=[N:4][CH:5]=2)=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 9845Trifluoroacetic anhydrideHCID 58882991Methyl 3-amino-5-[(4-fluorophenyl)methyl]pyridine-2-carboxylate

Product 1

HCID 69482769HCID 69482769, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared from methyl 3-amino-5-[(4-fluorophenyl)methyl]-2-pyridinecarboxylate as described in Example 89, Steps 9-10 by reacting with trifluoroacetic anhydride, followed by alkylation with methyl iodide and subsequent deprotection upon heating in the presence of MeOH.

Sources & evidence

ORD record
ord-6019ec6ec64342209b6bd7f8f7238341
Source dataset
uspto-grants-2014_04
Patent number
US08691991B2

Reaction notes

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