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HRID236468

反应详情

EQUATION

反应方程式

HRID 236468 的结构方程式

REACTANTS

反应物

6
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1
HCID70878

Carbobenzoxyphenylalanine

C17H17NO4

结构：CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)O
HCID90234

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

C15H21NO5

结构：COC(=O)[C@H](C)N.Cl
HCID2733257

Methyl (S)-2-aminopropanoate hydrochloride (1:1)

C4H10ClNO2

结构：COC(=O)[C@H](C)NC(=O)[C@H](COCc1ccccc1)NC(=O)OC(C)(C)C
HCID54537467

未命名化合物

结构：COC(=O)[C@H](C)NC(=O)[C@@H](N)COCc1ccccc1.O=C(O)C(F)(F)F
HCID131715028

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](C)NC(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
HCID131715027

未命名化合物

收率 74%

PROCEDURE

实验过程

First, Boc-Ser(OCH2C6H5)-OH (4.93 g, 16.7 mmol) was coupled to H-Ala-OCH3.HCl (2.80 g, 20.0 mmol) by a mixed anhydride procedure to yield an oil, 6.1 g. Boc-Ser(OCH2C6H5)-Ala-OCH3 was then deblocked with trifluoroacetic acid, and the resulting product, H-Ser(OCH2C6H5)-Ala-OCH3 trifluoroacetate (6.15 g, 15.6 mmol), was coupled to Z-Phe-OH (3.89 g, 13.0 mmol) using a mixed anhydride procedure. This product was crystallized from ethyl acetate to yield 5.4 g of Z-Phe-Ser(OCH2C6H5)-Ala-OCH3 (m.p. 158°-159°).

WORKUP

后处理

  1. customto yield an oil, 6.1 g
  2. customThis product was crystallized from ethyl acetate