反应详情

A solution of Example 42C (2.0 g, 3.9 mmol) and copper(I) cyanide (1.047 g, 11.69 mmol) in DMF (19 mL) was heated in a microwave for 7 hours at 160° C. Afterwards the mixture was poured in water (700 mL) and then concentrated ammonium hydroxide (40 mL) was added and the solution extracted with EtOAc. The organic extract was dried, filtered, concentrated and the residue purified by flash chromatography (silica gel, EtOAc/hexanes) to afford 1.23 g (78%) of the title compound. MS (ESI) m/z 406 (M+H)+.

1. extractionthe solution extracted with EtOAc
2. extractionThe organic extract
3. customwas dried
4. filtrationfiltered
5. concentrationconcentrated
6. customthe residue purified by flash chromatography (silica gel, EtOAc/hexanes)