Hydrochloric Acid → Diisopropylamino-acetic acid hydrochloride

HRID 2364929Notes

Reaction equation

HRID 2364929 reaction equation
C([O:5][C:6](=[O:15])[CH2:7][N:8]([CH:12]([CH3:14])[CH3:13])[CH:9]([CH3:11])[CH3:10])(C)(C)C.[ClH:16]>O>[ClH:16].[CH:9]([N:8]([CH2:7][C:6]([OH:15])=[O:5])[CH:12]([CH3:13])[CH3:14])([CH3:10])[CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11333389HCID 11333389, compound

Product 1

HCID 46735981Diisopropylamino-acetic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.4 g (25 mMol) diisopropylamino-acetic acid tert-butylester 2 was stirred with 6.25 ml (75 mMol) 12 M HCl in 25 ml water for 2.5 h at 60° C. After distillation in vacuo of water and excess of HCl, the residue was dried with toluene azeotropically.

Workup

  1. distillationAfter distillation in vacuo of water
  2. dry with materialexcess of HCl, the residue was dried with toluene azeotropically

Sources & evidence

ORD record
ord-ebb2f625df644252aacb55878745cfe1
Source dataset
uspto-grants-2014_04
Patent number
US08697604B2

Reaction notes

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