Lithium hydroxide, monohydrate → HCID 67495523, compound

HRID 2365223Notes

Reaction equation

HRID 2365223 reaction equation
O.[OH-].[Li+].C[O:5][C:6]([C:8]1[N:9]([CH3:28])[N:10]=[C:11]([O:13][CH2:14][C:15]2[N:16]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[N:17]=[N:18][C:19]=2[CH3:20])[CH:12]=1)=[O:7]>O.C1COCC1>[F:27][C:24]1[CH:23]=[CH:22][C:21]([N:16]2[C:15]([CH2:14][O:13][C:11]3[CH:12]=[C:8]([C:6]([OH:7])=[O:5])[N:9]([CH3:28])[N:10]=3)=[C:19]([CH3:20])[N:18]=[N:17]2)=[CH:26][CH:25]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67495619HCID 67495619, compound

Product 1

HCID 67495523HCID 67495523, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of lithium hydroxide monohydrate (146 mg, 3.48 mmol) in water (6 mL) was added dropwise to a suspension of 5-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (600 mg, 1.74 mmol) in THF (6 mL). The reaction mixture was then stirred at room temperature for 2 h and was then evaporated and the residue dissolved in water, acidified with HCl (1N), and the resulting precipitate filtered off to afford the title product (544 mg, 95%) as a white solid. MS: m/e=330.2 [M−H]−.

Workup

  1. customwas then evaporated
  2. dissolutionthe residue dissolved in water
  3. filtrationthe resulting precipitate filtered off

Sources & evidence

ORD record
ord-0a4aeb7d6a714ddaa9bee86f181b2eb7
Source dataset
uspto-grants-2014_04
Patent number
US08697696B2

Reaction notes

Loading…