4-Aminotetrahydropyran → HCID 57329924, compound

HRID 2365241Notes

Reaction equation

HRID 2365241 reaction equation
[CH3:1][C:2]1[N:3]=[C:4](/[CH:10]=[CH:11]/[C:12]2[N:13]([CH3:23])[N:14]=[N:15][C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[S:5][C:6]=1[C:7]([OH:9])=O.[NH2:24][CH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[O:28]1[CH2:29][CH2:30][CH:25]([NH:24][C:7]([C:6]2[S:5][C:4](/[CH:10]=[CH:11]/[C:12]3[N:13]([CH3:23])[N:14]=[N:15][C:16]=3[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)=[N:3][C:2]=2[CH3:1])=[O:9])[CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 67496730HCID 67496730, compound

Product 1

HCID 57329924HCID 57329924, compoundYield 66%

Procedure

As described for example 10 g, 4-methyl-2-[(E)-2-(3-methyl-5-pyridin-2-yl-3H-[1,2,3]triazol-4-yl)-vinyl]-thiazole-5-carboxylic acid (56 mg, 0.17 mmol), was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (46 mg, 66%) which was obtained as a light yellow solid. MS: m/e=411.2 [M+H]+.

Sources & evidence

ORD record
ord-8bcb2973b65f4b02a1096c1ca12acb86
Source dataset
uspto-grants-2014_04
Patent number
US08697696B2

Reaction notes

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